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作为PCSK9抑制剂的降脂小化合物的鉴定和评估

Run Xu1, Xutong Wang2, Jin Gao1

  • 1State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), College of Pharmacy, and Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China; Department of Pharmacology (SKLFZCD, State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China; Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China.

Journal of advanced research
|November 23, 2025
PubMed
概括

一种新的四化类昆化合物B11,有效降低胆固醇和甘油三,毒性最小. 它为高脂血症治疗提供了一个有希望的非他类替代品,即使与他类药物结合使用.

关键词:
455692 氨基酸是一种氨基酸B11 B11 是一个很好的方法.组合疗法是一种联合疗法.超脂血症是因为高脂血症在PCSK9中乌比奎丁是一种蛋白酶体.

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