辛诺米亚 (Cynomorium songaricum) 聚糖通过调节肠道微生物群来减轻高脂肪饮食引起的丸功能障碍
Pengfei Huan1, Wei Wang2, Yujuan Qi3
1Urology Department, Xuzhou Central Hospital Southeast University, Xuzhou, China; Department of Urology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
International journal of biological macromolecules
|November 23, 2025
概括
来自Cynomorium songaricum的新型多糖化物 (CSP1) 改善了肥胖小鼠的男性生育能力. CSP1重新平衡肠道微生物群,减少炎症,恢复生殖健康,为代谢生殖障碍提供了一种新疗法.
科学领域:
- 微生物学 微生物学
- 生殖生物学 生殖生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖会对肠道微生物群和男性生育能力产生负面影响.
- 与肥胖相关的不孕症的微生物向疗法尚未得到充分研究.
- 辛诺桑加里衍生的多糖 (CSP1) 是一种潜在的治疗剂.
研究的目的:
- 研究CSP1对肥胖引起的男性不孕症的治疗效果.
- 阐明涉及肠道微生物群调节的潜在机制.
- 评估CSP1作为代谢性生殖障碍的新疗法的潜力.
主要方法:
- 来自Cynomorium songaricum的CSP1的净化和结构特征.
- 将CSP1给高脂肪饮食 (HFD) 诱导的肥胖小鼠.
- 评估丸功能,肠道微生物群组成,肠道屏障完整性和炎症标志物.
- 便微生物群移植 (FMT) 验证肠道微生物群的作用.
主要成果:
- 在肥胖小鼠中,CSP1治疗改善了精子数量,运动性,水平和丸组织学.
- CSP1重塑了肠道微生物群,抑制了产生LPS的细菌,增加了产生SCFA的细菌.
- CSP1增强了肠道屏障功能 (上调的ZO-1,奥克卢丁,MUC2) 并降低了LPS转位.
- CSP1抑制了丸TLR4/MyD88/NF-κB信号通路和促炎性细胞因子.
- FMT证实CSP1的保护作用是由肠道微生物群介导的.
结论:
- 通过调节肠道微生物群和减少炎症,CSP1有效地减轻与肥胖相关的男性不孕症.
- CSP1代表了一种有前途的肠道微生物向治疗策略,用于代谢生殖障碍.
- 准肠道微生物生态系统为治疗与代谢疾病相关的男性不孕症提供了一种新的方法.
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