口服普雷尼索隆用于儿科桃体切除术中术后止痛管理:发表研究的元分析
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Pierre Pardessus1, Charlotte Benoit2, Kelly Brouns1
1University of Paris-Cité, France; Department of Anaesthesia and Intensive Care, Robert Debré University Hospital, Paris, France; FHU I2D2, Robert Debré University Hospital, Paris, France.
Anaesthesia, critical care & pain medicine
|November 23, 2025
概括
手术后的口服普雷迪尼索隆并不能有效地减少桃体切除术后儿童的疼痛或恶心. 由于证据有限和研究异质性,需要进一步研究.
科学领域:
- 儿科外科手术 儿科外科手术
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 首选用于儿科桃体切除术疼痛.
- 医生有时会选择术后的皮质类固醇,而不是NSAID.
- 这项研究调查了口服普雷迪尼索隆对儿童桃体切除术疼痛的疗效.
研究的目的:
- 为了评估小儿桃体切除术后口服普雷迪尼索隆的止痛效果.
- 评估普得尼索隆对术后疼痛强度,恶心和吐的影响.
- 为了确定普得尼索隆是否是NSAIDs的合适替代品.
主要方法:
- 进行了随机对照试验 (RCT) 的元分析.
- 研究比较了儿科桃体切除术患者的手术后口服普雷迪尼索隆与安慰剂.
- 疼痛强度,恶心和吐是主要结果;GRADE标准评估了证据质量.
主要成果:
- 口服普雷迪尼索隆在术后1,3或5-7天没有显著降低疼痛强度.
- 使用普雷迪尼索隆时,没有观察到术后恶心和吐的显著减少.
- 根据GRADE的评估,证据的质量从低到非常低不等.
结论:
- 手术后的口服普雷迪尼索隆在小儿桃体切除术后减轻疼痛方面并不有效.
- 高异质性和低质量的证据需要进一步研究.
- 目前的证据不支持使用口服普雷迪尼索隆来治疗这种症状.
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