Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Podospora bulbillosa keratitis: A case series with molecular confirmation from North-east India.

Indian journal of medical microbiology·2026
Same author

Reprogramming the lipid peroxidation product 4-ONE as a chemoselective cleavable crosslinker.

Nature communications·2026
Same author

Lysine methylation as a bidirectional switch.

Cell chemical biology·2026
Same author

Separating Signal from Noise: When Deep Learning Clarifies Physiology in MR Lymphangiography of Lower Extremity.

Radiology·2026
Same author

Clinical, gross, and microscopic findings in 7 owl monkeys (<i>Aotus spp</i>) with chronic biliary tree disease.

Veterinary pathology·2026
Same author

LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis.

Circulation research·2026

相关实验视频

Updated: Jan 10, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.6K

图像导向化学的最新发展和未来方向

Erik N K Cressman1, Monika Raj2, Erin H Seeley3

  • 1Department of Interventional Radiology, MD Anderson Cancer Center, Houston, Texas.

Journal of vascular and interventional radiology : JVIR
|November 23, 2025
PubMed
概括

热栓塞是一种使用体内化学的新方法,可以比传统的栓塞疗法更好地治疗癌症. 这种创新方法扩大了向疗法,包括非破坏性蛋白质修改,以获得更好的结果.

更多相关视频

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Published on: September 20, 2016

13.2K
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

6.9K

相关实验视频

Last Updated: Jan 10, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.6K
Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Published on: September 20, 2016

13.2K
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

6.9K

科学领域:

  • 干预性放射学 干预性放射学
  • 医学化学 医学化学
  • 在瘤学瘤学.

背景情况:

  • 过导管栓塞疗法在过去50年里有了显著的进化,有助于计算机断层扫描 (CT) 和磁共振 (MR) 等先进的成像技术.
  • 尽管技术进步,但在显微镜检查时,大量用栓塞治疗的瘤仍然含有可活的癌细胞.
  • 目前的局限性突显出需要在栓塞治疗中制定更有效的治疗策略.

研究的目的:

  • 引入热栓塞,一种新的方法,利用体内化学来提高栓塞疗法的疗效.
  • 探索基本化学原理的潜力,以开发更有效的癌症治疗方法.
  • 为有针对性的,以图像为指导的体内化学提出一个新的范式,超越破坏性干预,包括非破坏性应用,如蛋白质修饰.

主要方法:

  • 热栓塞的开发,一种利用体内化学和化学反应的技术.
  • 对新型治疗应用的意想不到的化学反应的研究.
  • 针对性,图像导向的 in vivo 化学的应用,用于破坏性和非破坏性干预.

主要成果:

  • 热栓塞证明了通过解决当前栓塞治疗的局限性来实现更有效的癌症治疗的潜力.
  • 新化学反应的发现为治疗研究开辟了新的途径.
  • 建议向非破坏性干预,如蛋白质修饰,进行范式转变.

结论:

  • 热栓塞在癌症治疗中是一个有前途的进步,它将化学与干预放射学相结合.
  • 这种方法扩大了图像引导干预的范围,包括精确的分子修饰.
  • 这一创新的战略促进了干预放射科医生,化学家和分子生物学家之间的跨学科合作,以促进未来的研究和临床应用.