精神病风险的认知轨迹:时间模式和与进展的关联
TianHong Zhang1, LiHua Xu2, YanYan Wei2
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China. zhang_tianhong@126.com.
Molecular psychiatry
|November 23, 2025
概括
患有精神病临床高风险 (CHR) 个体的认知衰退在第一年最明显. 早期的认知变化对于预测精神病的发展和为干预提供信息至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 认知障碍是从临床高风险 (CHR) 过渡到精神分裂症频谱精神病的一个关键因素.
- 了解随着时间的推移认知功能的动态变化对于开发预防策略至关重要.
研究的目的:
- 在三年内调查CHR个体的纵向认知轨迹.
- 为了比较转化为精神病的CHR个体 (CHR-C),没有转化为精神病的CHR个体 (CHR-NC) 和健康的对照人群 (HC) 之间的这些轨迹.
主要方法:
- 一项前性研究跟踪了43名CHR和18名HC参与者三年.
- 在五个时间点使用MATRICS共识认知电池 (MCCB) 的中文版本评估认知功能.
- 转化为精神病是主要的结果指标.
主要成果:
- 与CHR-NC和HC组相比,CHR-C个体在所有时间点都表现出明显更大的认知障碍.
- 在CHR-C个体中,最显著的认知衰退发生在第一年内.
- 增长曲线建模和重复测量ANOVA证实了对认知得分的显著群体和时间影响.
结论:
- 鉴定CHR后的第一年是监测认知变化的关键时期.
- 短期的认知轨迹变化是精神病的重要预测因素.
- 这些发现支持开发针对CHR个体认知缺陷的早期干预策略.
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