皮质控制的感觉通过血管活性肠道多表达内神经元在前皮质的前皮质
Yiwen Zhang1, Jiaqi Li1, You Wu1
1Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Neuroscience bulletin
|November 23, 2025
概括
前环皮质 (ACC) 中的表达血管活性肠 (VIP) 的内部神经元对于处理至关重要. 激活这些ACC VIP+神经元可以减少急性和慢性模型中的行为.
科学领域:
- 神经科学是一个神经科学.
- 的感知 的感知
- 身体的感觉 - - 身体的感觉.
背景情况:
- 前带带皮层 (ACC) 参与处理刺激.
- 在中ACC内部神经元群体的具体作用仍然在很大程度上是未知的.
研究的目的:
- 研究特定的ACC内部神经元群体对处理的贡献.
- 探索ACC中表达血管活性肠 (VIP) 内神经元对相关行为的调节作用.
主要方法:
- 利用c-Fos免疫标记和体内Ca2+成像来评估神经活动.
- 采用光遗传和化学遗传技术来操纵ACC VIP+神经元活动.
- 在小鼠中研究了急性 (希斯胺,氨酸) 和慢性 (接触性皮肤炎) 模型.
主要成果:
- 胰岛素和氨酸诱导的急性 significantly显著增强了ACCVIP+内神经元中的活性.
- 激活ACCVIP+神经元,可以减少基因组和非基因组急性的伤反应.
- 在慢性模型中观察到类似的神经活动和ACC VIP+神经元的行为调制.
结论:
- ACC VIP+神经元在调节与有关的影响和行为方面发挥着重要作用.
- 这些发现突出了ACC VIP+神经元作为慢性病的潜在治疗点.
- 了解ACC VIP+神经元的作用可能会导致耐火性慢性的新治疗方法.
相关概念视频
Sensory Functions of the Skin
7.8K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
7.8K
Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
Somatosensation
42.9K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
42.9K
Thermosensation
33.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.6K
Major Somatic Sensory Pathways
2.3K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.3K
Nociception
33.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.0K


