关于儿童固体器官移植患者疫苗可预防的呼吸道病毒感染的最新情况
Sanya J Thomas1,2, Daniel E Dulek3, Hayley A Gans4
1Pediatric Transplant & Immunocompromised Host Infectious Diseases Program, Pediatric Infectious Diseases, Columbia University Irving Medical Center and New York-Presbyterian, Morgan Stanley Children's Hospital, New York, New York, USA.
呼吸道病毒感染 (RVI) 对幼儿和儿科固体器官移植接受者 (PSOTR) 构成重大威胁. 本综述强调了在PSOTR中预防和管理疫苗可预防的RVI的新策略.
科学领域:
- 儿童传染病 儿童传染病
- 移植免疫学 移植免疫学
- 公共卫生 公共卫生
背景情况:
- 2021年,急性下呼吸道感染在4岁以下的儿童中造成725,557例死亡.
- 社区获得的呼吸道病毒感染 (RVI) 是儿童固体器官移植接受者 (PSOTR) 住院的主要原因.
- 在移植后的第一年,PSOTR从RVI中经历了14.5%的住院率.
研究的目的:
- 在PSOTR中审查RVI的新型预防和预防策略.
- 为疫苗可预防的RVI提供最新信息,包括流感,SARS-CoV-2和RSV.
- 通知国际儿科移植协会 (IPTA) 传染病委员会.
主要方法:
- 对当前文献和指导方针进行小型综述.
- 专注于疫苗可以预防的呼吸道病毒感染.
- 讨论预防和预防措施.
主要成果:
- 在幼儿中,RVI的全球负担显著.
- 在移植后的PSOTR中,RVI的高发病率.
- 对于RVI预防和预防的新兴策略.
结论:
- 疫苗可预防的RVI仍然是PSOTR的一个关键问题.
- 积极主动和新的策略对于管理RVI风险至关重要.
- 需要持续的研究和更新的指导方针来保护这个脆弱的人群.
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