维奥拉:一种天然的抗菌剂,通过膜形成喷雾剂增强其作用,用于局部应用
Kampanart Huanbutta1, Pornsak Sriamornsak2,3,4, Parapat Sobharaksha5
1Department of Manufacturing Pharmacy, College of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand.
BMC complementary medicine and therapies
|November 23, 2025
概括
这项研究开发了一种含有violacein的薄膜形成喷雾剂 (FFS),该喷雾剂对抗性微生物具有优越的抗菌活性. 灵活的,可剥皮的皮肤膜配方显示了改善患者对局部治疗的坚持的承诺.
科学领域:
- 制药科学 制药科学
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
背景情况:
- 抗生素耐药的微生物对全球健康构成重大挑战.
- 像violacein这样的天然化合物提供了潜在的抗菌解决方案.
- 来自Chromobacterium violaceum的violacein具有抗菌和抗氧化作用.
研究的目的:
- 开发和描述一种新型的紫载膜形成喷雾剂 (FFS).
- 为了创建一个灵活的,可剥皮的皮肤膜,以提高患者的坚持.
- 为了评估开发的FFS的抗菌疗效.
主要方法:
- 评估了violacein原始提取物的抗菌和抗氧化活性.
- 一个中央复合材料设计优化了FFS配方,使用Eudragit® RS 100,乙醇和甲.
- 描述了液体和薄膜的特性,包括粘度,干燥时间和机械强度.
主要成果:
- 优化的FFS配方产生了一种灵活,耐用的薄膜,具有合适的粘度和喷雾特性.
- 与商用克林达米辛溶液相比,含有紫的FFS在体外表现出更高的抗菌活性.
- 配方参数,如Eudragit® RS 100度和溶剂比率影响了薄膜的性能.
结论:
- 一种含有紫素的FFS成功地开发出来,产生了一种灵活,耐用的薄膜,具有显著的抗菌功效.
- FFS配方具有针对抗生素耐药性的局部应用的潜力.
- 这种创新方法可以改善患者对抗微生物药物治疗的遵守.
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