开发用于核取证应用的可现场部署的质谱系统,使用液体采样-大气压光放电作为离子源
Joseph V Goodwin1, Dehlia A Lang1, Suraj Shrestha1
1Department of Chemistry, Biosystems Research Complex, 105 Collings St, Clemson University, Clemson, South Carolina 29634, USA.
Applied spectroscopy
|November 23, 2025
概括
这项研究优化了一种便携式质谱系统,用于在现场测量活性化物. 液体采样-大气压发光放电 (LS-APGD) 与紧式质谱仪 (CMS) 结合,实现了和的低检测极限.
科学领域:
- 分析化学 分析化学
- 核化学 核化学 核化学
- 环境科学 环境科学
背景情况:
- 在核法医,保障和环境监测方面,实地测量化物至关重要.
- 像ICP-MS这样的传统方法具有高的运营开销,限制了现场应用.
- 现有的LS-APGD合器经常使用复杂,大型的质谱仪,不适合现场使用.
研究的目的:
- 为了优化液体采样-大气压光放电 (LS-APGD) 使用Advion ExpressionL紧式质谱仪 (CMS) 在现场检测活性化物.
- 建立一个便携式和高效的系统,用于在现场测量和.
- 报告CMS上的双电极LS-APGD的首次优化,以及使用LS-APGD对的首次分析.
主要方法:
- 使用实验设计方法优化LS-APGD放电条件.
- 进行了完整的因数研究,以优化紧式质谱仪的参数.
- 开发了一种改进的离子采样几何,以提高性能.
主要成果:
- 对和的检测限值达到0.2 ng.
- 证明了LS-APGD与Advion ExpressionL CMS的成功合.
- 建立了LS-APGD和CMS操作的独立优化.
结论:
- 优化的LS-APGD-CMS系统为现场的活性化物测量提供了可行的解决方案.
- 该系统满足或超过了美国环境保护局对饮用水分析的要求.
- 这项工作使得在各种环境和安全应用中更容易获得和更有效地监测活性化物.
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