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添加剂加速梅洛西卡姆释放从多 (尿) 纤维植入物用于急性疼痛管理

Courtney S Dziewior¹, Yize Li², Shaoyong Song²

¹Department of Chemistry, Duke University, Durham, North Carolina, USA.

Advanced healthcare materials

|November 24, 2025

概括

新的纳米纤维植入物将墨洛西卡姆直接输送到手术部位,提供持续的疼痛缓解. 与传统注射相比,这种局部方法显著减少疼痛和炎症.

科学领域:

生物材料科学生物材料科学
疼痛管理疼痛管理
药物输送系统药物输送系统

背景情况:

目前的疼痛管理通常依赖于阿片类药物,有效性和副作用有限.
非类固醇抗炎药 (NSAIDs) 提供了一个替代品,但需要有效的局部递送.
植入的设备可以在目标部位提供持续的药物释放.

研究的目的:

开发和评估含有 meloxicam 的聚乙烯尿素 (PEU) 纳米纤维,用于持续的局部药物输送.
在小鼠骨折模型中评估这些植入物在减少疼痛和炎症方面的有效性.
为了研究制造参数对梅洛西卡姆释放动力学的影响.

主要方法:

制造含有梅洛西卡姆的PEU纳米纤维,可控制聚合物特性和添加剂的变化.
在小鼠骨骨折模型中进行体内测试,将纳米纤维植入物与腹膜内 (IP) 和肌内 (IM) 注射梅洛西卡姆进行比较.
在血和周围肌肉组织中分析梅洛西卡姆度.
疼痛抑制和炎症标志物的评估 (Ptgs2表达,COX-2抑制).

主要成果:

与IP和IM注射相比,含有梅洛西卡姆的PEU纳米纤维在三天内表现出优异的疼痛抑制.
肌肉组织活检显示,治疗后一天,局部度很高.
在周围肌肉组织中观察到显著减少Ptgs2表达和COX-2抑制.

结论:

带有局部梅洛西卡姆的PEU植入物可以长时间抑制疼痛和炎症.
这种局部化输送系统为手术疼痛管理提供了一个有前途的替代方案.
开发的纳米纤维技术显示了增强局部NSAID传递的潜力.

关键词:

疼痛管理疼痛管理添加剂的添加剂是什么这是一个很好的方法. bupivicaineine.有控制释放的释放.药物输送是药物输送的过程.聚乙烯 (聚乙烯,聚乙烯,聚乙烯,聚乙烯,聚乙烯,聚乙烯,聚乙烯,聚乙烯,聚乙烯)

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