维生素D3补充剂调节多发性硬化症中炎症蛋白CHI3L1/YKL-40和氧化应激状态
Sevda Asadpour1, Mehrdokht Mazdeh2, Jamshid Karimi3
1Department of Clinical Biochemistry, Medicine School, Hamadan University of Medical Sciences, Hamadan, Iran.
Neuropsychopharmacology reports
|November 24, 2025
概括
多发性硬化症患者的维生素D3补充剂降低了炎症标志物CHI3L1和氧化应激. 这表明维生素D3通过提高抗氧化能力,可能是MS的有益辅助疗法.
科学领域:
- 神经免疫学 神经免疫学
- 生物化学 生物化学
- 临床营养学 临床营养学
背景情况:
- 多发性硬化症 (MS) 涉及慢性神经炎症和氧化应激.
- 维生素D已知具有潜在的免疫调节和抗氧化作用.
- 维生素D对MS中CHI3L1 (YKL-40) 的特定影响需要进一步研究.
研究的目的:
- 评估8周维生素D3补充剂对MS患者血清CHI3L1水平的影响.
- 评估维生素D3补充后氧化应激标志物和抗氧化酶活动的变化.
- 探索维生素D水平和这些生物标志物在MS之间的关系.
主要方法:
- 一个单臂前后临床试验,涉及35名多发性硬化症患者 (30-56岁).
- 参与者每周服用5万IU口服维生素D3,持续8周.
- 测量了血清25(OH) D,CHI3L1,氧化应激标志物 (TOS,MDA) 和抗氧化酶 (TAC,SOD,CAT,GPx).
主要成果:
- 维生素D3补充剂显著增加了血清25(OH) D水平 (p < 0.001).
- 血清CHI3L1度降低了21.7% (p < 0.001),同时减少了氧化应激标志物 (TOS,MDA) 和增强了抗氧化能力 (TAC,SOD,CAT,GPx).
- 在25(OH) D和CHI3L1,TOS和MDA之间发现了显著的逆相关性.
结论:
- 补充维生素D3有效增加了MS患者的维生素D水平.
- 补充导致CHI3L1和氧化应激标志物的显著减少.
- 这些发现支持维生素D3作为MS的潜在辅助疗法,针对关键的病理途径.
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