印度西北部淋巴细胞疾病的趋势:COVID-19是否改变了诊断格局?
Abhishek P Singh1, Jaydeep R Damor2, Pankaj Beniwal3
1Senior Resident, Department of Nephrology, Sawai Man Singh (SMS) Medical College, Udaipur, Rajasthan, India, Orcid: https://orcid.org/0000-0003-1893-0305.
The Journal of the Association of Physicians of India
|November 24, 2025
概括
现在,IgA脏病是印度西北部最常见的原发性淋巴细胞疾病,超过了最小变化疾病. 这项研究强调了病的发展趋势和COVID-19大流行对活检的影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 病理学 病理学 病理学
- 流行病学 流行病学
背景情况:
- 全球范围内,淋巴细胞疾病对慢性病有着显著的贡献.
- 从历史上看,最小变化疾病 (MCD) 在印度西北部普遍存在.
- 不断发展的诊断和COVID-19大流行可能影响了疾病模式.
研究的目的:
- 从2020年至2024年分析质细胞疾病的临床病理学谱.
- 将当前数据与历史数据 (2008-2013) 进行比较.
- 评估大流行对活检活动和疾病分布的影响.
主要方法:
- 925个脏活检 (2020-2024) 的回顾性分析和与622个活检 (2008-2013) 的比较.
- 使用光显微镜和免疫光染色.
- 将诊断分类为原发性淋巴细胞疾病 (PGD),次发性淋巴细胞疾病 (SGD) 和其他疾病,记录综合征 (NS) 和急性损伤 (AKI) 等临床表现.
主要成果:
- 淋巴结膜炎仍然占主导地位 (93.9%),PGD分布发生了显著转变.
- IgA脏病增加到15.4%,成为主要的PGD,而MCD下降到8.1%.
- 焦点细分型淋巴结核硬化 (FSGS) 增加到12.4%,糖尿病病 (DN) 增加到3.1%,活检量在疫情期间暂时下降.
结论:
- 在印度西北地区观察到球体疾病模式的显著演变.
- 强调需要改善对脏活检和先进诊断工具的获取.
- 强调在印度建立国家脏活检注册的重要性.
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