隐藏的风险:潜在的认知特征和结构性大脑年龄揭示了中年代谢综合征的脆弱性
Isabelle Gallagher1, Makenna B McGill1, Janelle T Foret1
1Department of Psychology, The University of Texas at Austinhttps://ror.org/00hj54h04, Austin, TX, USA.
Journal of the International Neuropsychological Society : JINS
|November 24, 2025
概括
中年成人代谢综合征 (MetS) 与加速的大脑衰老和认知变化有关. 早期发现脆弱性是干预的关键,这是由大脑预测的年龄差异和认知分析所表明的.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 认知老龄化 认知老龄化
背景情况:
- 代谢综合征 (MetS) 是一种已知的认知能力下降和大脑晚年衰老的风险因素.
- 早期识别那些在中年容易受到认知障碍的MetS患者目前具有挑战性.
研究的目的:
- 应用潜质分析 (LPA) 来确定中年成人MetS的认知表现模式.
- 利用MRI衍生的大脑预测年龄指标来评估这一群体中的结构性大脑衰老.
主要方法:
- 分析了40-65岁的有或没有MetS的认知正常成年人.
- 潜形状分析 (LPA) 根据调整的认知测试分数确定了四个认知子组.
- 脑预测年龄差异 (PAD) 使用MRI扫描和brainageR软件进行计算.
主要成果:
- 在所有认知特征中,MetS的患病率有所不同,在低记忆力和全球平均水平组中更高.
- 与MetS患者相比,没有MetS的个体表现出较年轻的大脑年龄.
- 高甘油与较大的PAD特别相关,在40岁至54.6岁之间,这种关联是显著的.
结论:
- 认知分析和大脑预测年龄指标可以在中年成人中早期发现MetS的脆弱性.
- 这些发现凸显了早期干预策略对MetS患者的关键重要性,以缓解认知衰退.
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