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Updated: Jan 10, 2026

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AbAgym:一个精心策划的数据集,用于对抗体-抗原复合物的突变分析

Gabriel Cia1, Dong Li1, Simón Poblete2,3

  • 1Computational Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.

mAbs
|November 24, 2025
PubMed
概括

一个新的手动策划的数据集,AbAgym,提供324k个抗体-抗原突变来训练计算模型. 目前的模型在预测结合亲和力变化方面表现出有限的成功,强调需要考虑生物复杂性.

关键词:
抗体抗原复合体 抗体抗原复合体突变是发生在突变中的突变.

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Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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