中国内脏肥胖指数在预测心血管疾病风险方面优于传统的人类指数:一项前性队列研究
Xiang Li1, Aikedan Maimaiti1, Yong Ling1,2
1Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Diabetes/metabolism research and reviews
|November 24, 2025
概括
中国的内脏脂肪指数 (CVAI) 强烈预测了中国成年人的心血管疾病 (CVD) 风险. 在心血管疾病预测方面,CVAI的表现优于BMI和腰围等传统指标,特别是在女性中.
科学领域:
- 心脏病学和公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 准确的风险预测工具对于早期干预和预防策略至关重要.
- 传统的人类指数在评估内脏脂肪和心血管疾病风险方面存在局限性.
研究的目的:
- 评估中国内脏脂肪指数 (CVAI) 与中国人口中发生心血管疾病的相关性.
- 为了比较CVAI与传统人体指数 (BMI,WC,WHR,WHtR) 的预测性能.
主要方法:
- 一项前性队列研究,涉及35551名没有心血管疾病病史的中国成年人.
- 考克斯的比例危险模型和受限立方线分析了指数与心脏病,心脏病和中风风险之间的关联.
- 亚组分析检查了跨年龄,性别,高血压和糖尿病组的关联.
- 接收器操作特征 (ROC) 分析使用AUROC,NRI和IDI评估预测性能.
主要成果:
- 在混调整后,CVAI的1-SD增加与发生性心脏病,心脏病和中风的最高风险增加有关.
- 在一般人群中,CVAI对心血管疾病的预测性表现 (AUC) 显著高于BMI和WC.
- 与女性的WHR相比,CVAI也显示出更好的预测能力.
结论:
- 在中国人群中,CVAI与发生心血管疾病风险的关联比传统的人类指数更强.
- CVAI显示出作为CVD事件的优越预测因素的巨大潜力,特别是在女性中.
- 这些发现支持CVAI在心血管疾病风险分层和公共卫生倡议中的有用性.
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