维生素C减轻甲酸盐暴露诱导的干扰精子发生在Medaka
Sourav Chakraborty1, Beh Reh2, Santosh Anand1
1Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, United States.
Environmental science & technology
|November 24, 2025
概括
暴露于甲酸盐会通过破坏丸和破坏基因表达来损害男性的生殖能力. 补充维生素C可以防止这种毒性,强调其在生殖健康干预方面的潜力.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
背景情况:
- 内分泌干扰化学物质 (EDC) 对代谢和生殖健康构成风险.
- 甲酸 (KClO4) 是一种影响甲状腺功能的环境污染物,其对男性生殖的影响还未得到充分研究.
研究的目的:
- 为了研究丸损伤从慢性甲酸盐 (KClO4) 暴露在梅达卡 (Oryzias latipes).
- 确定维生素C是否可以减轻KClO4诱导的丸毒性和生殖功能障碍.
主要方法:
- 成年男性medaka暴露在KClO4 (0.01毫克/升,10毫克/升) 和KClO4以及维生素C (3毫克/升) 中21天.
- 评估受精成功,对丸进行组织学检查,并分析丸转录基因变化.
主要成果:
- 暴露于KClO4显著降低了受精率,并导致丸细胞病理变化,包括精卵管的失调.
- 转录组分析揭示了参与细胞粘附,染色体重塑,氧化应激和胚胎细胞发育的基因失调.
- 同时服用维生素C可以部分恢复丸形态,改善受精率,并使一些KClO4诱导的基因表达变化正常化.
结论:
- 暴露于KClO4诱导显著的丸毒性和生殖功能障碍在医学上.
- 维生素C对KClO4诱导的丸毒性具有保护作用,这表明可能需要基于抗氧化剂的干预措施来保护男性生殖健康.
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