用于普通感冒和急性性鼻炎的抗生素
1Department of General Practice and Primary Health Care, University of Auckland, Auckland, New Zealand.
The Cochrane database of systematic reviews
|November 24, 2025
概括
抗生素对普通感冒或急性性鼻炎没有好处. 它们增加了成年人感冒和所有年龄段的性鼻炎的不良影响,因此不推常规使用.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 抗生素通常用于急性上呼吸道感染 (URTI),如普通感冒,尽管缺乏经过证明的疗效.
- 人们仍然相信抗生素可以预防尿路感染病例中的二次细菌感染.
研究的目的:
- 评估抗生素对普通感冒症状的疗效与安慰剂.
- 评估抗生素对急性性和明显鼻炎结果的影响.
- 确定与URTI抗生素治疗相关的不良结果.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (CENTRAL,MEDLINE,EMBASE等) 进行了搜索. 在2013年2月之前进行研究.
- 包括对抗生素与安慰剂进行比较的RCT,用于急性URTI或急性性鼻炎.
主要成果:
- 抗生素在普通感冒治愈或症状持续方面没有比安慰剂更好的效果 (RR 0.83,95% CI 0.60至1.14).
- 抗生素使用增加了不良反应 (RR 1.8,95% CI 1.01至3.21),特别是在普通感冒的成年人中 (RR 2.62,95% CI 1.32至5.18).
- 对于急性性鼻炎没有显著的益处 (RR 0.73,95% CI 0.47至1.13) ,副作用增加 (RR 1.46,95% CI 1.10至1.94).
结论:
- 没有证据支持在任何年龄段对普通感冒或急性性鼻炎使用抗生素.
- 抗生素与显著的不良影响有关,特别是在普通感冒的成年人和所有年龄段的性鼻炎.
- 根据目前的证据,针对这些疾病不建议常规处方抗生素.
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