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Updated: Jan 10, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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艾滋病毒-1转录在艾滋病毒-1整合部位的宿主基因活性上占主导地位

Samuel Weissman1, Yang-Hui J Yeh1, Miriam Viazmenski1

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.

mBio
|November 24, 2025
PubMed
概括

尽管有效的抗逆转录病毒疗法 (ART),但HIV-1转录并没有沉默. 沉默HIV-1促进体对于抑制异常宿主基因表达和慢性免疫激活至关重要,为治愈HIV铺平了道路.

关键词:
克里斯普尔激活和抑制的作用艾滋病毒治愈 治愈艾滋病毒艾滋病毒-1整合站点插入性突变的突变发生.转录干扰是指转录干扰.

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