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肠道微生物群对心血管疾病的影响 - - 一个关于当前证据的小型综述
Shouhong Zhang1, Jing Li2, Liping Li2
1Department of Cardiology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China.
Frontiers in microbiology
|November 24, 2025
概括
肠道微生物群通过TMAO和SCFA等代谢物影响心血管疾病 (CVD) 风险. 虽然有希望,但基于微生物群的疗法需要更多的人体试验来证明对心血管疾病结果的临床益处.
科学领域:
- 微生物学 微生物学
- 心血管医学 心血管医学
- 肠道微生物组研究研究
背景情况:
- 肠道微生物组越来越被认为是心血管疾病 (CVD) 发展的关键因素.
- 益生菌类细菌及其代谢物为心血管疾病提供了潜在的治疗途径.
- 了解这些微生物的影响对于新的治疗策略至关重要.
研究的目的:
- 审查目前关于肠道微生物及其代谢物如何影响心血管疾病风险的证据.
- 阐明涉及微生物群介导的心血管疾病调节的生物学途径.
- 检查基于微生物群的干预措施对心血管健康的有效性.
主要方法:
- 来自动物模型和人类临床试验的当前证据的综合.
- 生物途径的解,包括TMAO,SCFA和胆酸代谢.
- 检查治疗策略,如饮食修改,FMT和药理学剂.
主要成果:
- 肠道微生物群通过特定的代谢途径影响高血压,动脉样硬化和心力衰竭.
- 对微生物群-心血管疾病相互作用的机制性见解是有希望的.
- 人类试验尚未始终显示微生物群调节对心血管疾病结果的显著临床益处.
结论:
- 肠道微生物组在心血管健康和疾病中发挥着重要作用.
- 需要进一步的研究来确定因果关系,并将发现转化为有效的临床治疗方法.
- 个性化,针对微生物群的治疗方法在未来有可能用于管理心血管疾病.
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