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肺结核使系统性硬化症中间歇性肺病复杂化:来自高结核负担国家的病例报告
Donny Ardika Novananda1, Garinda Alma Duta1, Resti Yudhawati Meliana1
1Pulmonology and Respiratory Medicine Department, Faculty of Medicine, Universitas Airlangga, RSUD Dr. Soetomo, Surabaya, Indonesia.
Case reports in pulmonology
|November 24, 2025
概括
系统性硬化症相关的间歇性肺病 (SSc-ILD) 可能因结核病 (TB) 而复杂化. 早期诊断和多学科护理对于在流行地区管理这种双重病理至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 系统性硬化症 (SSc) 是一种影响皮肤和内脏器官的纤维性疾病.
- 间歇性肺病 (ILD) 是SSc的一个主要并发症,增加了发病率和死亡率.
- 机会性感染,如结核病 (TB),使SSc-ILD管理复杂化,特别是在流行地区.
研究的目的:
- 报告SSc-ILD病例同时感染活性肺结核.
- 突出双重病理学的诊断挑战和管理策略.
主要方法:
- 一个45岁的女性被诊断出SSc-ILD的案例介绍.
- 高分辨率计算机断层扫描 (HRCT) 用于ILD模式识别 (NSIP模式).
- 肺结核的诊断确认使用酸快细菌涂抹和GeneXpert测试.
主要成果:
- 该患者出现了暗示SSc-ILD的症状,后来发展为活性肺结核.
- 人类肺结核试验显示了与非特异性间歇性肺炎模式一致的发现.
- 在SSc-ILD的治疗过程中确认了结核病的同时感染.
结论:
- 警对于免疫抑制患者至关重要,特别是在结核病流行环境中.
- 早期识别和协调的多学科护理 (风湿病学,肺病学,传染病) 对于SSc-ILD结核病患者的最佳结果至关重要.
- 这个案例有助于理解管理SSc-ILD的复杂性,因为SSc-ILD复杂于活跃的结核病.
相关概念视频
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis
Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

