运动对乳腺癌化疗引起的心脏毒性的缓解能力
Chen-Yue Qian1, Juan Fan2,3,4, Jing-Yi Guo1
1Department of Intensive Care Unit, Southern University of Science and Technology Yantian Hospital, Shenzhen, Guangdong, China.
Frontiers in cell and developmental biology
|November 24, 2025
概括
乳腺癌的化疗可以导致心脏问题. 运动可以帮助减少这些心脏毒性风险,但患者需要量身定制的心脏康复计划.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 运动生理学 运动生理学
背景情况:
- 乳腺癌的化疗药物减少死亡率,但增加心脏毒性风险.
- 常见的心脏毒性药物类别包括细胞循环抑制剂 (人类循环素,纳税素) 和HER2抑制剂 (特拉斯图祖马布,珀图祖马布).
- 心脏毒性表现为心力衰竭症状,如胸部不适,胀和呼吸障碍.
研究的目的:
- 审查用于乳腺癌的化疗药物的心脏毒性表现和机制.
- 检查运动方案在缓解化疗诱导的心脏毒性的有效性.
- 为突出乳腺癌幸存者的专业心脏康复的需要.
主要方法:
- 关于与人环素,税,HER2阻断剂和环胺相关的心脏毒性的文献综述.
- 对控制心脏毒性的运动干预措施 (有氧,抵抗,HIIT) 的分析.
- 检查运动诱导心脏保护背后的分子机制.
主要成果:
- 人环素通过活性氧物种诱导心脏毒性;HER2抑制剂也带来了重大风险.
- 运动计划,包括有氧运动,可以降低促炎因素的调节,并减轻心脏毒性.
- 现有的心脏康复计划往往没有特别关注乳腺癌患者的化疗诱导心脏毒性.
结论:
- 量身定制的运动计划对于在接受化疗的乳腺癌患者中控制心脏毒性至关重要.
- 针对特定患者的个人心脏康复可以抵消不良心血管影响.
- 需要进一步的研究和专门计划的开发,以改善幸存者的长期心血管健康.
相关概念视频
Exercise and Cardiovascular Response
3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Exercise and Cardiac Output
1.8K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.8K
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Cardiomyopathy VI: Nursing Management
302
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
302
Cardiomyopathy V: Interprofessional Care
316
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
316
Heart Failure Drugs: β-Blockers
741
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
741


