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集成的CIRCLE-seq与RNA-seq解读了AML中eccDNA的数量,定位和功能特征

Lijuan Gao1,2, Qiongyu Lu3, Hao Li4

  • 1National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in oncology
|November 24, 2025
PubMed
概括

外染色体圆形DNA (eccDNA) 在急性髓性白血病 (AML) 中升高,与基因失调和不良预后有关. 这项研究揭示了eccDNA.

关键词:
在AML,AML就是AML.在RNA-seqqq.一个圆形-seqq.这就是为什么eccDNADNA.预后 预后 预后

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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