尿源干细胞作为与年龄相关的退行和慢性疾病风险模型
Pengfei Yu1,2, Jiaqi Li1, Huifen Ding2
1The Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University Beijing 100069, China.
American journal of clinical and experimental urology
|November 24, 2025
概括
来自老年人或糖尿病患者的尿源干细胞显示功能减弱,这表明它是研究衰老和慢性病 (CKD) 风险的有价值模型.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 干细胞生物学 干细胞生物学
背景情况:
- 脏衰老会损害功能,增加慢性病 (CKD) 的易感性.
- 干细胞数量和功能下降是衰老的关键因素,但机制尚不清楚.
- 人类尿液衍生的干细胞/原始细胞 (USCs) 为再生医学提供了一个非侵入性的来源.
研究的目的:
- 通过USCs,研究前细胞的与年龄相关的退化.
- 来自老年/糖尿病捐赠者的USC与来自年轻,健康捐赠者的USC进行比较.
- 建立USC作为研究衰老和祖细胞功能障碍的模型.
主要方法:
- 在USC中评估了细胞增殖,活性氧物种 (ROS) 生产和衰老标志物.
- 从年长的健康,年长的糖尿病患者和年轻的健康个体中比较了USC.
- 评估了USCs形成具有管状结构的3D球体的能力.
主要成果:
- 来自老年和糖尿病捐赠者的USC显示出明显减少的增殖和升高的ROS水平.
- 在老年/糖尿病患者的USC中,β-银酸酶表达量的增加表明老化.
- 来自老年/糖尿病捐赠者的USC与年轻对照组相比显示3D球形形成受损.
结论:
- 来自老年人或糖尿病患者的USC作为研究衰老和祖细胞功能障碍的有价值模型.
- 这种USC模型可以帮助识别衰老和CKD风险的生物标志物.
- 这些发现可能会为未来的脏疾病的再生和治疗策略提供信息.
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