生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BB-12通过肠道微生物群调节减轻糖尿病视网膜病变:关于肠-视网膜轴的证据
Jiayi Lin1, Yaqi Cheng1, Yumin Ling2
1Department of Ophthalmology, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China.
Frontiers in cellular and infection microbiology
|November 24, 2025
概括
生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BB-12补充剂在糖尿病小鼠中改善了肠道微生物群,减少了肥胖,并增强了视力. 这表明益生菌在治疗糖尿病视网膜病变和代谢失调方面可能发挥作用.
科学领域:
- 微生物学 微生物学
- 眼科医生 眼科 眼科
- 代谢疾病 代谢疾病
背景情况:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BB-12以维持肠道屏障功能和调节炎症而闻名.
- 糖尿病视网膜病变 (DR),糖尿病的眼部并发症,与代谢失调有关.
- BB-12与眼部疾病,特别是DR之间的联系仍然未被充分探索.
研究的目的:
- 研究BB-12补充剂对全身糖尿病症状的影响.
- 评估BB-12对糖尿病视网膜病变进展的影响.
- 在糖尿病模型中分析BB-12对肠道微生物群稳定性的影响.
主要方法:
- 糖尿病db/db小鼠被用于监测代谢参数和肝/脂质概况.
- 用ERG,OCT和HE染色来评估视网膜功能和形态.
- 分别通过流细胞计和16S rRNA测序分析了Treg/Th17平衡和肠道微生物群组成.
主要成果:
- 补充BB-12导致肥胖和肝脏肥胖症的减少.
- 在视网膜血管健康和视觉功能方面观察到改善.
- 在糖尿病小鼠中,BB-12调节了Treg/Th17平衡,改善了肠道失调.
结论:
- 补充BB-12证明了与糖尿病相关的全身和眼部并发症的潜在益处.
- 这些发现凸显了肠道微生物群在糖尿病相关疾病中的调节作用.
- 对肠-视网膜轴的进一步研究是有必要的,以探索治疗策略.
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