中度严重的血小板缺血预示着多发性骨髓瘤的不良结果
Grace M Ferri1, Cenk Yildirim2,3, Nhan V Do1,2,3
1Department of Medicine Section of General Internal Medicine Boston Medical Center Boston Massachusetts USA.
EJHaem
|November 24, 2025
概括
多发性骨髓瘤 (MM) 患者的血小板计数可以预测生存结果. 诊断时和治疗期间血小板数量低表明预后较差,即使使用标准疗法.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 生物标志物 生物标志物
背景情况:
- 多发性髓瘤 (MM) 涉及恶性血细胞改变骨髓微环境.
- 这种相互作用减少了造血干细胞,并影响了巨核细胞的分化,可能导致MM患者的血小板缺血.
- 新型MM疗法需要生物标志物来评估骨髓微环境.
研究的目的:
- 评估周围血液血小板计数作为多发性骨髓瘤 (MM) 的预后标志物.
- 评估诊断时和MM治疗期间血小板计数与整体存活率的相关性.
主要方法:
- 在2000年至2019年期间诊断的14313名MM患者的回顾性分析.
- 血小板计数被分类为中度至重度的血小板减少 (<100),轻度的血小板减少 (100-149),正常的 (150-349),和血小板减少 (≥350每微升).
主要成果:
- 诊断时有25%的患者存在血小板缩,与整体存活率 (OS) 较低相关.
- 在随访期间持续或新的血小板缺血也预测了较差的生存状况.
- 在基线中,中度至重度的血小板缺血对OS产生了负面影响,不论是标准疗法还是干细胞移植.
结论:
- 周围血液血小板计数是多发性骨髓瘤 (MM) 容易获得的预后标志物.
- 血小板计数可以帮助预测MM患者的生存结果.
更多相关视频
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
30.4K
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
7.2K
相关概念视频
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...