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Updated: Jun 10, 2026

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从人类精子单分子测序中直接识别新的移动元素插入

Stacy Li1,2, Kenneth Aston3, Joseph G Gleeson4

  • 1Department of Integrative Biology, University of California - Berkeley.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

我们直接测序精子配体,以识别新的移动元素插入 (MEI),而无需进行家族研究. 父亲的年龄显著增加了Alu的逆转换率,揭示了与年龄相关的突变增加.

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相关概念视频

Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...