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Updated: Jan 10, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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使用主动学习的真菌转录激活剂的进化发现和表征

Lucas Waldburger1,2, Hunter Nisonoff3, Marissa Zintel4

  • 1Department of Bioengineering, University of California, Berkeley, CA, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

我们开发了ADhunter,这是一个新的模型来识别转录激活剂 (ADs) 并指导进化采样. 这种方法在多种不同的真菌基因组中扩展了功能注释,提高了生物发现的预测模型稳定性.

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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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