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Updated: Jan 10, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
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抗蛋白酶的阿扎胺GLP-1模拟物改善了饮食诱导肥胖的代谢控制

Mingzhu He1, Kai Fan Cheng1, Sonya VanPatten1

  • 1The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

阿扎提升了对降解的稳定性,为开发新的以基蛋白为基础的疗法提供了有前途的策略. 这项研究表明,基于阿扎的葡萄糖类-1受体激动剂 (GLP-1RAs) 在临床前模型中改善了代谢健康.

关键词:
作为GLP-1受体激活剂 (GLP-1RA) 的一种.这是一种阿扎普提德 (Azapeptide).高脂肪饮食引起的肥胖 (HF-DIO)

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