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Updated: Jun 12, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
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在皮肤活检中检测可能发生的神经元基因表达变化的检测,这些患者患有帕克利塔塞尔诱导的外周神经病变

Andi Wangzhou1, Surendra Dasari2, Diana Tavares-Ferreira1

  • 1Department of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson TX, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

皮肤活检提供了一种新的方法来研究神经病痛患者的神经元变化. 这项研究发现,皮肤活检中的基因表达差异与背部根结节神经元相关,有助于理解疼痛机制.

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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...