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Updated: Jul 9, 2026

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

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大规模发现神经增强剂用于 cis 调节疗法

Troy A McDiarmid1,2, Nicholas F Page3,4,5, Florence M Chardon1,2

  • 1Department of Genome Sciences, University of Washington, Seattle, WA, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

这项研究使用基于CRISPR的基因激活 (CRISPRa) 识别了神经发育障碍 (NDD) 基因的活跃人类神经增强剂. 这些发现为开发针对NDD的基于CRISPR的 cis调节疗法 (CRT) 提供了资源.

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