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相关概念视频

Carbohydrate Metabolism01:36

Carbohydrate Metabolism

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
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Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

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Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
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Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

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Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Carbohydrate Absorption01:25

Carbohydrate Absorption

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Carbohydrates are essential macronutrients that serve as the body's primary energy source. Their digestion begins in the mouth, where salivary amylase partially breaks down complex carbohydrates such as starch into smaller oligosaccharides. This mechanical and enzymatic activity prepares carbohydrates for further processing in the gastrointestinal tract.
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
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Carbohydrate Catabolism01:30

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Carbohydrate catabolism is a fundamental process in cellular metabolism that enables energy extraction from glucose through two primary pathways: cellular respiration and fermentation. Both pathways begin with glycolysis, which operates independently of oxygen availability.Glycolysis: A Shared Starting PointGlycolysis is an oxygen-independent process that breaks down glucose into two molecules of pyruvic acid. During this process, a net gain of two ATP molecules and two NADH molecules is...
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Author Spotlight: Advances in Brain Energy Metabolism Research Using the Drosophila Model
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碳水化合物适应驱动肝脑轴成熟.

Hongmei Cui, Zheng Wu, Yuannyu Zhang

    bioRxiv : the preprint server for biology
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    PubMed
    概括

    肝脏 肝脏是肝脏中的一个部分.

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    相关实验视频

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    科学领域:

    • 生物化学 生物化学
    • 代谢调节 代谢调节 代谢调节
    • 发育生物学是发展生物学.

    背景情况:

    • 哺乳动物在出生后适应富含碳水化合物的饮食.
    • 器官间代谢程序的协调还没有得到很好的理解.

    研究的目的:

    • 调查肝脏的成熟及其在协调新陈代谢中对生命早期发育的作用.
    • 确定肝脏代谢适应的关键调节者.

    主要方法:

    • 从新生儿到成年老鼠的时间解析的转录组和代谢组分析.
    • 研究了线粒体RNA核糖核糖酶LACTB2.2.的作用.
    • 恢复电子输送链 (ETC) 功能的评估影响.

    主要成果:

    • 断奶后,小鼠肝脏迅速获得氧化和排毒能力,由LACTB2.2调节.
    • LACTB2维持了线粒体RNA的稳定性和ETC子单元的表达,这对氧化代谢至关重要.
    • 缺少LACTB2会影响葡萄糖利用,导致代谢毒性,影响大脑发育,导致致命性,特别是在男性中.

    结论:

    • 对于适应碳水化合物饮食来说,LACTB2-依赖的肝脏线粒体成熟是必不可少的.
    • 这个过程调整了肝脏和大脑的新陈代谢,以支持早期发育.
    • 恢复ETC功能可以改善代谢功能障碍的情况下的生存率.