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Updated: Jan 10, 2026

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长期 Locus Coeruleus 刺激加剧了 PS19 小鼠中的 Tau 病理

Yuhan Nong1, Steven Wellman1, Hong Zhang2

  • 1Department of Biomedical Engineering.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

在阿尔茨海默氏病 (AD) 的小鼠模型中,长期刺激状位 (LC) 会使记忆和突触可塑性恶化. 这种刺激增加了Tau病理和神经炎症,表明它可能会加剧AD的进展.

关键词:
在 AEPEP 中,AEPEP 是一个专业组织.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在 LTP LTP 中.这里是Locus coeruleus的地方.在PS19小鼠.化学遗传刺激的化学刺激.北上腺氨酸 (norepinephrine) 是一种病症是一种病症.

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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