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Updated: Jan 10, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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矩阵刚度会诱导内皮细胞网络衰老.

Jiyeon Song1, Alexandra N Rindone2, Ya Guan1

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

组织硬化驱动内皮细胞中的细胞衰老,影响衰老和疾病. 针对Notch信号通路提供了机械老化的潜在干预.

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A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells11:51

A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells

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Cell-matrix's Response to Mechanical Forces

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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