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Updated: Jan 10, 2026

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
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细胞外矩阵刚性通过TYK2-介导的机械传导控制乳腺癌转移

Zhimin Hu1, Hannah E Majeski1, Aida Mestre-Farrera1

  • 1Department of Pharmacology, Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0819, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

雅努斯酶TYK2通过在细胞外基质刚度低的情况下定位到细胞膜中来抑制乳腺癌转移. 抑制TYK2有助于癌症的扩散,突出显示TYK2抑制剂的患者需要进行乳腺癌查.

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