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Updated: Jan 10, 2026

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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在狼中性粒细胞中U12型分离的失调

Luz P Blanco1, Binod Regmi2, Carmelo Carmona-Rivera1

  • 1Systemic Autoimmunity Branch, at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

系统性红斑狼 (SLE) 中性粒细胞的功能受损,原因是轻微的 spliceosome 缺陷影响了依赖 U12 的拼接. 这导致NADPH氧化酶活性降低和免疫调节的改变,突出显示小结合体.

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