Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Stages of General Anesthesia01:22

Stages of General Anesthesia

1.4K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.4K
General Anesthesia: Overview01:24

General Anesthesia: Overview

554
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
554
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

964
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
964
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

554
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
554
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

554
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
554
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

2.6K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dynamic Electrocortical States and Paradoxical Complexity during Desflurane Anesthesia.

Anesthesiology·2026
Same author

Author Correction: Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation.

Nature communications·2026
Same author

An open fMRI resource for studying human brain function and covert consciousness under anesthesia.

Scientific data·2026
Same author

Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation.

Nature communications·2025
Same author

Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans.

Nature communications·2024
Same author

Role of Thalamus in Human Conscious Perception Revealed by Low-Intensity Focused Ultrasound Neuromodulation.

bioRxiv : the preprint server for biology·2024
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jan 10, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

11.4K

在desflurane麻醉期间,动态的电皮质状态和矛盾的复杂性.

Duan Li1, Anthony G Hudetz1

  • 1Center for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, MI.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括
此摘要是机器生成的。

总麻醉会导致自发的大脑状态的转变,包括在深度麻醉期间的矛盾激活状态. 这些发现揭示了麻醉度之外的复杂动态,有助于意识监测和恢复.

更多相关视频

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.5K
Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

2.6K

相关实验视频

Last Updated: Jan 10, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

11.4K
Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.5K
Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

2.6K

科学领域:

  • 神经科学是一个神经科学.
  • 麻醉学 麻醉学
  • 计算神经科学是一种神经科学.

背景情况:

  • 了解全身麻醉对皮质电活动的影响是阐明无意识机制的关键.
  • 皮质活动表现出自发的状态过渡,即使在恒定的麻醉水平.
  • 这些大规模的大脑状态转换的空间和时间动态仍然不太了解.

研究的目的:

  • 为了研究在全身麻醉下电皮活动的动态.
  • 描述皮层状态转换的时空组织和时间动态.
  • 探索麻醉深度和大脑状态复杂性之间的关系.

主要方法:

  • 在不同度的desflurane麻醉期间从老鼠大脑中记录的外周电皮图.
  • 长期植入32通道灵活电极阵列,用于高分辨率数据采集.
  • 主要组件分析和基于密度的聚类确定了不同的皮质状态.
  • 规范化的Lempel-Ziv复杂度量化了信号变化,过渡概率评估了时间动态.

主要成果:

  • 确定了七种不同的皮质状态,其中六种与麻醉深度普遍相关.
  • 在深度麻醉期间观察到具有降低角功率和增加复杂性的悖论性激活状态.
  • 皮质活动表现出高状态持久性 (99.36%),非随机过渡主要在轻度或深度麻醉状态内.

结论:

  • 在麻醉下,皮质电活动不仅取决于度,还涉及自发动态和矛盾状态.
  • 麻醉诱导复杂的大脑动态,表明正在进行的自发皮质重组.
  • 研究结果提供了监测意识,操纵大脑状态和促进麻醉恢复的见解.