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Updated: Jan 10, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Published on: August 16, 2018

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一个偏向的全调节器作为分子剂起作用,诱导β2AR二元化

Jiemin Shen1,2, Teja Nikhil Peddada1,2, Konstantin E Komolov3,2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

一种新型的小分子AP-7-168作为分子剂,促进β2-上腺素受体 (β2AR) 分解. 这种由连接体诱导的二分化稳定了受体,防止了β-arrestin合和偏向信号通路.

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