不确定性塑造了运动皮质中的神经动力学,在达到时.
Tapas J Arakeri1, Jean M Dill1, Katalin M Gothard1
1Departments of Physiology and Neuroscience, College of Medicine, University of Arizona, Tucson, AZ, USA 85724.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
背前运动皮层中的大脑活动在不确定性下达到运动时调整运动计划. 更高的不确定性导致更窄的神经轨迹,表明更快地重新规划准确的目标导向行动.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知神经科学 认知神经科学
背景情况:
- 自愿运动往往发生在关于目标的不完整信息.
- 大脑必须根据不断变化的条件灵活调整运动计划和正在进行的运动.
研究的目的:
- 为了研究关于达到目标的不确定性如何影响神经准备和执行.
- 为了检查背部前运动 (PMd) 和主运动 (M1) 皮层的神经活动,在达到任务的不同目标不确定性.
主要方法:
- 从PMd和M1记录的神经活动在一个 rhesus performing一个达到任务.
- 使用概率线索和延迟目标呈现操纵目标不确定性.
- 分析了与不确定性水平相关的人口神经轨迹.
主要成果:
- 在PMd中神经轨迹,但不是M1,呈现出逐渐减少扩张的准备状态,不确定性更高.
- 尽管改变了准备状态,但执行的移动在不确定性级别中保持一致.
- 在神经状态空间中确定了一个特定的维度,它代表了准备和执行期间的不确定性水平.
结论:
- 在PMd中神经准备适应目标不确定性,更窄的轨迹可能有助于更快地重新规划.
- 这些发现表明,在信息不完整的情况下,神经机制可以适应目标导向的运动.
- 运动规划和执行可以灵活地由大脑调整以应对不同程度的环境不确定性.
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