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Updated: Jan 10, 2026

Generation, Maintenance, and Characterization of Human Pluripotent Stem Cell-derived Intestinal and Colonic Organoids
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将数学建模与人类肠道新型干细胞系统结合起来,以了解平面细胞极性期间的反调节

Keith A Breau1, Emma G Dunahey1, Henry V Fosnocht2

  • 1Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

这项研究模拟了平面细胞极性 (PCP) 复合体,揭示了其组件如何驱动细胞对齐的新见解. 实验强调了PCP在人类肠道生物学中的不被重视的作用.

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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