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Updated: Jan 10, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
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发现了调节AP1转录因子ΔFOSB的DNA结合和释放的小分子和可药物槽

Sean McNeme, Yun Young Yim, Ashwani Kumar

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    研究人员在ΔFOSB转录因子上发现了一个新的可用药物的位点,使小分子抑制剂的开发成为可能. 这一发现为针对与 ΔFOSB 活动相关的慢性疾病提供了一个新的策略.

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