许多循环的和代谢产物是宿主衍生物
Jenna E AbuSalim1,2,3, Kellen Olszewski3, Salma Youssef1,2
1Department of Molecular Biology, Princeton University, Princeton, NJ 085.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
主体细胞,不仅仅是肠道细菌,产生关键的醇和代谢物. 这一发现揭示了对这些重要信号分子在循环中的重要宿主贡献.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 人体生理学 人体生理学
背景情况:
- 印醇和代谢产物主要归因于细菌对氨基酸的消化,如氨酸和氨酸/氨酸.
- 这些代谢物具有重要的生理作用,包括AhR信号 (indoles) 和与健康体重 () 的关联.
- 主体对这些代谢物的循环池的贡献仍然不够.
研究的目的:
- 研究宿主在产生循环中的英多尔和代谢物的作用.
- 区分宿主和微生物对这些代谢物池的贡献.
主要方法:
- 稳定同位素追踪在哺乳动物细胞培养和小鼠模型中使用.
- 在小鼠和人类患者中分析了代谢物水平.
- 评估了微生物组干扰对代谢物水平的影响.
主要成果:
- 哺乳动物细胞被证明可以合成酸甲基酸盐,酸甲基酸盐,酸甲基酸盐和酸碳酸盐.
- 在小鼠和人类患者中,这些宿主衍生代谢物的水平在很大程度上不受微生物组变化的影响.
- 细菌的新陈代谢对于生产烯酸酸盐,自由醇,和醇至关重要.
结论:
- 宿主新陈代谢是循环中的酸,乳酸,酸和碳酸的主要来源.
- 细菌的新陈代谢对于合成特定的英和衍生物,如烯酸酸盐和自由的英/至关重要.
- 对于某些代谢物类,宿主对循环的英多尔和代谢物池的贡献是显著的和主要的.
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