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Updated: Jan 10, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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由RNA Pol I抑制介导的NPM1错位化改变了染色质景观

Pierre-Olivier Estève1,2, Sagnik Sen1,2, Karthikeyan Raman1,2

  • 1New England Biolabs Inc, 240 County Road, Ipswich, MA 01938, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

RNA聚合酶I抑制会破坏核细胞结构和染色体组织. 这导致基因组标记,DNA甲基化和基因组可访问性发生变化,影响核架构.

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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Types of RNA01:23

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Overview
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Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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