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Updated: Jan 10, 2026

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NF-κB通过Drosophila的染色质调节来抑制营养依赖的转录程序

Xiangshuo Kong, Conghui Li, Jason Karpac

bioRxiv : the preprint server for biology

|November 24, 2025

概括

天生的免疫转录因子,如核因子kB (NF-kB),可以在表观遗传上抑制细胞代谢. 这一发现揭示了微调营养物质依赖的新陈代谢适应反应于饮食的新机制.

科学领域:

免疫学免疫学免疫学
代谢调节代谢调节代谢调节
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

免疫和代谢系统共同进化,免疫信号通路控制细胞代谢.
天生的免疫转录因子,如核因子 κB (NF-κB),是代谢适应饮食和营养的关键调节者.

研究的目的:

为了研究多 NF-κB (Relish) 在调节依赖营养的代谢转录程序中的作用.
阐明NF-κB控制细胞代谢和代谢适应的表观遗传机制.

主要方法:

染色体可访问性基因组学以确定NF-κB的监管目标.
在代谢基因基因位点上进行素乙化分析.
有针对性的基因查,以识别相互作用的蛋白质,如基因素脱乙酶6 (HDAC6).

主要成果:

草 NF-κB (Relish) 抑制了依赖营养的代谢转录程序,其作用与其正规激活器功能不同.
NF-κB/Relish通过基因素乙化调制限制了色素的可访问性,从而限制了代谢基因转录.
海斯脱乙酶6 (HDAC6) 与NF-κB/Relish相互作用,通过限制染色质可访问性来抑制代谢转录程序.

结论:

天生的免疫转录因子可以在表观遗传上抑制细胞代谢.
这种由NF-κB进行的表观遗传控制微调了依赖营养的代谢适应.
NF-κB和HDAC6之间的相互作用在代谢控制中提供了一个新的调节轴.

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