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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Immunological Memory01:23

Immunological Memory

15.0K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
15.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
83.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K

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SIMPLseq: a high-sensitivity Plasmodium falciparum genotyping and PCR contamination tracking tool.

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Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

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相关实验视频

Updated: Jan 10, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

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记忆调节T细胞在复发性疟疾中被重新编程成保护性Tfh类效应体.

Nana Appiah Essel Charles-Chess, Anthony A Ruberto, Carson Bowers

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括
    此摘要是机器生成的。

    记忆调节T细胞 (Tregs) 在复发疟疾期间切换功能. 这些细胞从免疫抑制转变为保护性作用,增强抗体反应并改善Plasmodium控制.

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    Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
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    In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
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    相关实验视频

    Last Updated: Jan 10, 2026

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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    Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
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    In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
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    In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

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    科学领域:

    • 免疫学 免疫学 免疫学
    • 传染性疾病 传染性疾病
    • 寄生虫学的寄生虫学

    背景情况:

    • 调节性T细胞 (Tregs) 通常在原发性菌感染期间抑制免疫力,阻碍了寄生虫的控制.
    • 在复发性疟疾感染中Tregs的功能尚不清楚.

    研究的目的:

    • 为了研究在复发性等杆菌感染期间记忆Tregs (mTregs) 的作用和功能.
    • 阐明mTregs在再感染的背景下调整其功能的机制.

    主要方法:

    • 在人类和小鼠疟疾模型上的纵向研究.
    • 分析mtreg扩张,表观遗传重编程和分化.
    • 研究了Foxp3+ Tregs向Bcl6+毛囊T辅助细胞 (Tfh) 类似细胞的转变.

    主要成果:

    • 记忆Tregs (mTregs) 在重新感染时会扩大并经历表观遗传重编程.
    • mTregs 分化为类似Tfh的效应细胞,促进生殖中心 (GC) 反应.
    • 这些mTreg衍生的Tfh类细胞增强了Plasmodium特异性抗体的产生和寄生虫的控制.

    结论:

    • 记忆Tregs表现出适应性可塑性,在复发疟疾期间从免疫抑制转向保护作用.
    • 这种mTregs的功能可塑性对于在再次感染时有效控制Plasmodium至关重要.
    • 这些发现揭示了慢性寄生虫感染中免疫调节的新机制.