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Updated: Jan 10, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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Bhlhe40协调T细胞程序与不同的CD4和CD8T细胞对抗PD-1与抗CTLA-4的需求

Akata Saha1, Tomoyuki Minowa1, Alexander S Shavkunov1

  • 1Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

转录调节剂Bhlhe40在抗PD-1和抗CTLA-4癌症免疫治疗期间在CD4和CD8T细胞中发挥着不同的作用. Bhlhe40对T细胞效应器功能和代谢适应性至关重要,影响免疫治疗的疗效.

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