环境新 调节在导航过程中的快速皮质可塑性
Alexander Attinger1, Antonia Drinnenberg2, Can Dong1
1Department of Neurobiology, Stanford University, Stanford, CA, 94305, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
神经可塑性塑造了大脑中的空间表征. 经验决定了后皮质 (RSC) 和初级视觉皮质 (V1) 如何适应新环境,平衡稳定性和灵活性.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 系统神经科学 系统神经科学
背景情况:
- 当动物在新环境中导航时,它们在后皮层 (RSC) 和初级视觉皮层 (V1) 迅速形成空间表征.
- 神经可塑性和经验在塑造这些表征中的确切作用仍然不清楚.
研究的目的:
- 调查RSC和V1.1中的空间表示的可塑性.
- 了解体验如何在空间学习过程中调节神经可塑性.
主要方法:
- 在导航虚拟现实的小鼠中利用了双光子成像和全息光遗传学.
- 启用了神经活动的实时,细胞分辨率控制.
主要成果:
- 针对2/3层神经元的有针对性的刺激,使神经活动偏向于新环境中的特定位置.
- 在RSC中的5层神经元显示出无关环境熟悉性的可塑性.
- 塑性机制是层特定的,并且依赖于经验.
结论:
- 新皮层空间表征平衡了熟悉环境中的稳定性和对新信息的灵活性.
- 这些发现为理解空间导航中的经验依赖可塑性提供了一个框架.
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