多原子集成揭示了人类胎盘代谢在整个妊娠期间的动态变化
Mariana Parenti1, Sam Rosen2, Maya Pettes2
1Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
胎盘代谢在整个怀孕期间发生显著的变化,其中关键的途径在三个月之间发生变化. 综合代谢和转录基因数据揭示了对胎儿发育至关重要的动态代谢转变.
科学领域:
- 人类胎盘生物学
- 代谢学 代谢学 代谢学
- 怀孕研究研究 怀孕研究
背景情况:
- 胎盘代谢需求在怀孕期间动态演变.
- 之前的研究主要集中在长期胎盘或细胞系,不研究发育变化.
- 了解妊娠期间的胎盘代谢组变化对于监测怀孕健康至关重要.
研究的目的:
- 为了研究胎盘代谢和代谢物轨迹在正常的人类怀孕的三个月.
- 通过综合的代谢和转录基因数据,识别妊娠期间改变的代谢途径.
- 为了全面了解整个怀孕期间的胎盘代谢功能.
主要方法:
- 在胎盘活检中针对372种代谢物的水性代谢分析,跨越三个季度.
- 液体染色学-并联质谱学 (LC-MS/MS) 用于代谢物量化.
- 路径分析和多奥姆集成与转录组数据进行生物学解释.
主要成果:
- 胎盘样本按季度分组,揭示了5种不同的代谢物轨迹.
- 77%的可检测代谢物 (149/193) 在三个月内显示出显著的差异.
- 关键的代谢途径,包括氨基酸,脂质和NAD代谢,在整个妊娠期间都被动态调节.
结论:
- 胎盘代谢物丰度和通路活动在整个怀孕期间发生了很大变化.
- 综合的多原子数据提供了关于妊娠期间动态代谢适应的见解.
- 这些发现提高了对胎盘功能的理解,并可以为未来的怀孕研究提供信息.
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