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Updated: Jan 10, 2026

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
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Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

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人类Dicer1热点突变诱导了miRNA功能的损失和收益

David Jee1,2, Seungjae Lee1,2, Dapeng Yang1

  • 1Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

与癌症相关的Dicer1突变破坏了微RNA (miRNA) 处理,导致链偏差并增强了基因沉默. 这项研究揭示了这些突变如何影响miRNA-3p链负载和功能.

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