甲状腺衰老中的性别差异及其对甲状腺疾病的影响:基因调节网络的见解
Enakshi Saha1, Marouen Ben-Guebila2,3, Chen Chen2
1Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC 29208, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
甲状腺老化显示了性别特异的基因调节差异,女性在40岁和60岁左右经历了显著的变化. 这些性别偏差的调节模式会影响甲状腺疾病的风险,特别是在女性身上.
科学领域:
- 内分泌学和分子生物学
- 基因组学和生物信息学
- 癌症研究 癌症研究
背景情况:
- 甲状腺疾病表现出明显的性别和年龄差异,女性患病率更高.
- 无塑性甲状腺癌 (ATC) 的风险随着年龄的增长而增加,而哈西莫托甲状腺炎 (HT) 在30-50岁之间达到顶峰.
- 根据年龄的变化表明甲状腺老化偏向于性别,以及性别之间的基因调节差异.
研究的目的:
- 为了研究健康甲状腺组织中与性别特定的衰老相关的基因调节变化.
- 描述这些变化如何影响已知性别和年龄特定差异的甲状腺疾病风险,例如HT和ATC.
主要方法:
- 使用BONOBO进行共同表达分析,构建个体特异性基因调节网络.
- 将转录因子 (TF) 基因数据和蛋白质-蛋白质相互作用与PANDA集成,以推断TF驱动的网络.
- 对健康甲状腺和HT和ATC中年龄和性别特定的调节模式的分析.
主要成果:
- 甲状腺基因调节,特别是与癌症相关的和免疫/代谢途径,随着年龄变化而变化非线性,并且性别之间存在显著差异.
- 女性在40岁和60岁之间表现出明显的调节性转变,由性激素受体驱动.
- 在HT中,衰老调节模式与疾病模式相对立,而在ATC中,它们对齐;在HT中,女性调节模式与疾病状态更紧密地对齐.
结论:
- 甲状腺基因调节受到年龄和性别的影响,影响免疫和代谢过程.
- 这些性别特异性的调节变异有助于性别之间的甲状腺疾病风险差异.
- 这些发现强调了针对性查和预防甲状腺疾病的预防策略的必要性.
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