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Updated: Jun 4, 2026

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins
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Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

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主要人类自然杀手细胞的特定基因组工程用于可编程的抗瘤功能

Vincent Allain1,2,3, Allison G Rothrock1,2, Pierre-Louis Bernard1,2

  • 1Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

研究人员开发了一种新的CRISPR/Cas9和AAV6方法,用于工程自然杀手 (NK) 细胞. 这种方法可以在NK细胞中进行精确的基因编辑,增强它们对抗癌症的采用细胞疗法的潜力.

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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...